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Statistical Physics of Biomolecules: An Introduction, by Daniel M. Zuckerman
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From the hydrophobic effect to protein-ligand binding, statistical physics is relevant in almost all areas of molecular biophysics and biochemistry, making it essential for modern students of molecular behavior. But traditional presentations of this material are often difficult to penetrate. Statistical Physics of Biomolecules: An Introduction brings "down to earth" some of the most intimidating but important theories of molecular biophysics.
With an accessible writing style, the book unifies statistical, dynamic, and thermodynamic descriptions of molecular behavior using probability ideas as a common basis. Numerous examples illustrate how the twin perspectives of dynamics and equilibrium deepen our understanding of essential ideas such as entropy, free energy, and the meaning of rate constants. The author builds on the general principles with specific discussions of water, binding phenomena, and protein conformational changes/folding. The same probabilistic framework used in the introductory chapters is also applied to non-equilibrium phenomena and to computations in later chapters. The book emphasizes basic concepts rather than cataloguing a broad range of phenomena.
Focuses on what students need to know now
Students build a foundational understanding by initially focusing on probability theory, low-dimensional models, and the simplest molecular systems. The basics are then directly developed for biophysical phenomena, such as water behavior, protein binding, and conformational changes. The book’s accessible development of equilibrium and dynamical statistical physics makes this a valuable text for students with limited physics and chemistry backgrounds.
- Sales Rank: #1320578 in Books
- Brand: Brand: CRC Press
- Published on: 2010-06-02
- Original language: English
- Number of items: 1
- Dimensions: 9.30" h x 1.00" w x 6.20" l, 1.45 pounds
- Binding: Hardcover
- 356 pages
- Used Book in Good Condition
About the Author
University of Pittsburgh, Pennsylvania, USA
Most helpful customer reviews
5 of 5 people found the following review helpful.
Outstanding introduction to stat phys
By StruBinf
I highly recommend this book. It is accessible to new comers, provides crystal clear, yet fairly rigorous explanations of difficult topics and - most importantly - it clarifies the simple probabilistic reasoning that is at the heart of statistical physics. Without the underlying framework of probability theory, many concepts in statistical physics seem to emerge from thin air and thus become difficult to grasp. The author has well understood this, and uses appropriate probabilistic explanations to great advantage.
4 of 4 people found the following review helpful.
Great book on the topic
By David L Mobley
I find this a really helpful book on the topic. Zuckerman is a great teacher in this format, and the book is well written and interesting. He has a carefully chosen concrete example (butane) that he revisits again and again to illustrate different points. The range of topics considered is good, and this is material that is not necessarily easily found in a single other book. I also like Dill's Molecular Driving Forces, which deals with statistical thermodynamics, but this is a somewhat more advanced and more thorough treatment that deals with a different set of material. Dill's book is great for what it is, but this is too. Honestly, I really need to have both books on my shelf. I'd be more comfortable using this for a graduate level class than Dill's book, which is often more introductory.
Anyway, this isn't a review of the Dill book -- the comparison is just to say that that's the only other book I'm aware of that's really at all comparable, and the two are for different audiences. This is for a more advanced audience (though not to say too advanced -- a talented undergraduate or beginning graduate student can understand it easily) and is perhaps more thorough and traditional (though not in a bad way), while at the same time bringing Zuckerman's unique talents to the table. Definitely a book I'm going to continue using a lot.
4 of 4 people found the following review helpful.
and each time through I like it more and more
By Alan Grossfield
This will be the third time I've taught from this book, and each time through I like it more and more. Dan did an excellent job of boiling statistical physics down to the subset necessary for graduate level biophysics students, and combined just the necessary level of mathematical rigor with clear, intuitive explanations. The best book of its kind around!
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